Metformin associated weight loss
We examined its long-term safety and tolerability along with weight loss, and change in waist circumference during the DPP and its long-term follow-up. Its most common side effects are gastrointestinal ( 1 ). In the Diabetes Prevention Program (DPP), metformin reduced the development of diabetes by 31% over an average of 2. To date, metformin is indicated only for diabetes management and not for weight loss in individuals with or without diabetes. clinical trials, about 4% of participants were unable to continue metformin due to adverse effects. Gastrointestinal symptoms were more common in metformin than placebo participants and declined over time. Metformin is associated with weight loss when used to treat diabetes and thus differs from a number of other antidiabetic medications that are associated with weight stability or gain ( 2, 3 ). Metformin treatment has not been associated with hypoglycemia unless used in conjunction with other glucose-lowering medicines (sulfonylureas or insulin). Complete free continuing medical education and professional development courses. These symptoms are generally transient, resolve spontaneously, and can often be avoided by gradual escalation of dosage. Serious adverse events are infrequent and generally limited to lactic acidosis, which occurs only in persons with renal or hepatic insufficiency or other contraindications.
Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study. In U. Decreases in hemoglobin and hematocrit in the metformin group occurred during the first year following randomization, with no further changes observed over time. By using this website, you agree to the use of cookies. This website uses cookies to deliver its services as described in our Cookie Policy. During the DPP, average hemoglobin and hematocrit levels were slightly lower in the metformin group than in the placebo group. S. Metformin is an established treatment for diabetes with a good safety profile ( 1 ). Access free mobile and online drug and disease references. Abstract OBJECTIVE Metformin produced weight loss and delayed or prevented diabetes in the Diabetes Prevention Program (DPP). Weight loss is related to adherence to metformin and is durable for at least 10 years of treatment.
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